Platelets, bleeding & clotting disorders, Blood Transfusion
- What is the normal lifespan of human platelets? Ans: 9~12 days
- The best laboratory investigation that measures the intrinsic system's factors VIII, IX,XI and XII. Ans: The Activated Partial Thromboplastin Time (APTT)
- Passage of IgG antibodies from the maternal circulation across the placental barrier into the foetal circulation. Here they react with and damage foetal red cells. What is this condition? Ans: Haemolytic Disease of the Newborn (HDN)
- In this disorder abnormal platelet function is associated with low factor VIII clotting activity. Ans: Von Willebrand's disease
- The Direct Coomb's test is used for diagnosing which clinical conditions? Ans: Haemolytic disease of the newborn, Auto-immune haemolytic anaemia, Drug induced immune haemolytic anemia and haemolytic transfusion reactions.
- Platelets release the contents of their granules on exposure to collagen or thrombin. The contents of the granules are.. Ans: ADP, Serotonin, Fibrinogen, Lysozomal enzymes and Platelet factor 4.
- Donated blood is mandatorily tested for which comminicable infective disease? Ans: Anti-HIV, HBsAg, Anti HCV, Syphilis, malaria/ filariasis.
- The disease that occurs due to either deficiency or abnormal function of factor IX. Ans: Christmas Disease (Haemophilia- B)
- What is the Blood Group of the mother that causes HDN? Ans: Mother is Rh -ve and has high plasma titre of anti-D
- What is the storage temperature and lifespan for platelet concentrate? Ans: 22'C in platelet aigitator for 5 days.
- A man with blood group A marries a woman whose blood group is B. What are the likely blood groups that the child born to them have? Ans: AB, A, B or O.
- NAme the clotting factors that require Vit K for synthesis. Ans: Factors II, VII, IX, X
- In this disease, the platelets get trapped in microcirculation and the number of circulating platelets get consumed. Subsequently there is ischaemic organ damage, mainly the kidney and brain. Ans: Disseminated Intravascular Coagulation.
* The above questions and answers are provided by Dr Srikumar. Any enquiries please contact him at his faculty zone. Thanks!
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korwoi
